Particulate Ag:DC receptors Exogenous Particulate antigen (Ag) DC receptors recognizing apoptotic cells Interaction of particulate antigens with dendritic cell receptors Authored: Garapati, P V, 2011-03-28 Dendritic cells (DCs) and macrophages recognize and phagocytose apoptotic cells/invading microorganisms using a variety of receptors including lectins, Mannose receptor (MR) (Stahl & Ezekowitz. 1998), CD36 (Savill 1997), CD14 (Devitt et al. 1998), scavenger receptor A (SR-A) (Platt et al. 1996) and integrin alphaVbeta5 (Savill et al. 1992, Savilli et al. 1990), then cross-present cell-associated antigens to CD8+ T cells. Ligands on apoptotic cell like sugars, phosphatidylserine and surface-bound thrombospondin (TSP) are recognized by these receptors and induce rearrangements in the actin cytoskeleton that lead to the internalization of the particle. Edited: Garapati, P V, 2011-03-28 Pubmed1383273 Pubmed1688647 Pubmed18268517 Pubmed18331591 Pubmed7678924 Pubmed8901603 Pubmed9523111 Pubmed9763615 Reactome Database ID Release 431236958 Reactome, http://www.reactome.org ReactomeREACT_111137 Reviewed: Desjardins, M, English, L, 2011-05-13