MHC class I HC:Calnexin/BiP:Erp57 MHC HC:B2M:Erp57 Interaction of beta-2-microglobulin (B2M) chain with class I HC Authored: Garapati, P V, 2010-10-29 Edited: Garapati, P V, 2010-10-29 Interaction of calnexin (CNX) with MHC class I HC stabilizes it and facilitates the association of the beta2 microglobulin component (B2M). The two chains are linked noncovalently via interaction of B2M and the alpha3 domain of MHC HC. After formation of the HC:B2M heterodimer, the MHC complex dissociates from CNX. Pubmed10064069 Pubmed14681859 Pubmed2450918 Reactome Database ID Release 43983146 Reactome, http://www.reactome.org ReactomeREACT_75898 Reviewed: Elliott, T, 2011-02-10 Chaperones calnexin/BiP