PathwayStep921 Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 Co-transport (influx) of glucose and Na+ ions by SGLT2 PathwayStep4893 PathwayStep4894 Na+-dependent glucose transporters Authored: Jassal, B, 2009-07-10 Edited: Jassal, B, 2009-07-10 Pubmed17222166 Reactome Database ID Release 43428808 Reactome, http://www.reactome.org ReactomeREACT_19165 Reviewed: He, L, 2009-08-24 Two gene families are responsible for glucose transport in humans. SLC2 (encoding GLUTs) and SLC5 (encoding SGLTs) families mediate glucose absorption in the small intestine, glucose reabsorption in the kidney, glucose uptake by the brain across the blood-brain barrier and glucose release by all cells in the body.<br><br>Na+-dependent glucose transporters (SGLTs) mediate secondary active glucose transport in the small intestine and kidney . They use the downhill Na+ gradient to transport glucose across intestinal and renal membranes. Three genes in the SLC5 family (SLC5A1, 2 and 9) encode proteins that transport glucose (and other substrates) with Na+ (Wright EM et al, 2007). Transport (influx) of glucose, galactose, and sodium ions by SGLT1