HMIT co-transports myo-inositol with a proton Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 Co-transport (influx) of myo-inositol and two Na+ ions by SMIT PathwayStep4898 PathwayStep4897 PathwayStep4896 Inositol transporters Authored: Jassal, B, 2009-07-17 Edited: Jassal, B, 2009-07-17 Myo-Inositol is a neutral cyclic polyol, abundant in mammalian tissues. It plays important roles; it is a precursor to phosphatidylinositols (PtdIns) and to the inositol phosphates (IP), which serve as second messengers and as key regulators of many cell functions. It can also serve as a compatible osmolyte during volume regulation in many tissues where cells are exposed to hyperosmotic conditions. Three members of the glucose transporter families are inositol transporters. Two (SMIT1 and SMIT2) couple myo-inositol transport with two Na+ ions. Unlike SMIT1, SMIT2 also transports D-chiro_inositol. The third transporter (HMIT), couples myo-inositol transport with a proton. Reactome Database ID Release 43429593 Reactome, http://www.reactome.org ReactomeREACT_19188 Reviewed: He, L, 2009-08-24