I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol A group of inositol phosphatases dephosphorylate inositol 1,4,5-trisphosphate (I(1,4,5)P3) to inositol 1,4-bisphosphate (I(1,4)P2). The group of inositol phosphatases involved are: inositol polyphosphate 5-phosphatase OCRL-1 (OCRL), phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J), and synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 (SYNJ1).<br><br>The following lists the above proteins with their corresponding literature references: OCRL (Zhang et al. 1995, Zhang et al. 1998, Schmid et al. 2004); INPP5J (Mochizuki & Thompson 1999); SYNJ1 (Schmid et al. 2004). Authored: Williams, MG, 2011-10-28 EC Number: 3.1.3.56 Edited: Williams, MG, 2011-10-28 Pubmed10593988 Pubmed15474001 Pubmed7761412 Pubmed9430698 Reactome Database ID Release 431855174 Reactome, http://www.reactome.org ReactomeREACT_150347 Reviewed: Challiss, John, 2012-11-09 Reviewed: Wundenberg, Torsten, 2012-11-06