1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol Authored: Williams, MG, 2011-10-28 Diphosphoinositol polyphosphate phosphohydrolases, also known as nucleoside diphosphate-linked moiety X motif (NUDT) proteins, dephosphorylate inositol diphospho-pentakisphosphate (PP-IP5) to inositol 1,2,3,4,5,6-hexakisphosphate (IP6). The NUDT proteins involved are: nucleoside diphosphate-linked moiety X motif 3 (NUDT3), 4 (NUDT4), 10 (NUDT10), and 11 (NUDT11). The reactants consumed are: inositol 1-diphospho-2,3,4,5,6-pentakisphosphate (1-PP-IP5) and 3-diphospho-1,2,4,5,6-pentakisphosphate (3-PP-IP5).<br><br>The following lists the above proteins with their corresponding literature references: NUDT3 (Safrany et al. 1999, Safrany et al. 1998, Yang et al. 1999, Caffrey et al. 2000), NUDT4 (Caffrey et al. 2000), NUDT10 (Leslie et al. 2002, Hidaka et al. 2002) and NUDT11 (Leslie et al. 2002, Hidaka et al. 2002). Edited: Williams, MG, 2011-10-28 Pubmed10419486 Pubmed10585413 Pubmed10777568 Pubmed12105228 Pubmed12121577 Pubmed9822604 Reactome Database ID Release 432023971 Reactome, http://www.reactome.org ReactomeREACT_150167 Reviewed: Challiss, John, 2012-11-09 Reviewed: Wundenberg, Torsten, 2012-11-06 1/3-PP-IP5