5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus Authored: Williams, MG, 2011-10-28 Edited: Williams, MG, 2011-10-28 In the nucleus, inositol hexakisphosphate kinase 1 (IP6K1) and 2 (IP6K2) phosphorylate inositol 5-diphospho-1,2,3,4,6-pentakisphosphate (5-PP-IP5) to inositol 5-triphospho- 1,2,3,4,6-pentakisphosphate (5-PPP-IP5) (Saiardi et al. 2001, Draskovic et al. 2008) and IP6K2 (Saiardi et al. 2001, Draskovic et al. 2008). While this reaction has been demonstrated to occur in vitro, the extent to which it occurs in vivo is less clear. Pubmed11502751 Pubmed18355727 Reactome Database ID Release 431855224 Reactome, http://www.reactome.org ReactomeREACT_150137 Reviewed: Challiss, John, 2012-11-09 Reviewed: Wundenberg, Torsten, 2012-11-06