I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane Authored: Williams, MG, 2011-10-28 EC Number: 3.1.3.56 Edited: Williams, MG, 2011-10-28 Pubmed15474001 Pubmed1718960 Pubmed7721860 Reactome Database ID Release 431855213 Reactome, http://www.reactome.org ReactomeREACT_150158 Reviewed: Challiss, John, 2012-11-09 Type II inositol-1,4,5-trisphosphate 5-phosphatase (INPP5B) is attached to the plasma membrane where it dephosphorylates inositol 1,3,4,5-tetrakisphosphate (I(1,3,4,5)P4) to inositol 1,3,4-trisphosphate (I(1,3,4)P3 (Jefferson & Majerus 1995, Ross et al. 1991, Schmid et al. 2004). INPP5B is isoprenylated at its C-terminus for membrane attachment.