Alpha-N-acetylglucosaminidase (NAGLU) hydrolyses N-acetyl-D-glucosamine residues from heparan sulfate Alpha-N-acetylglucosaminidase (NAGLU) hydrolyses the non-reducing, terminal N-acetyl-D-glucosamine residue from heparan sulfate. The active form of the enzyme (77kDa) is derived from a 82kDa precursor (Weber et al. 1996). Defects in NAGLU cause of mucopolysaccharidosis type IIIB (MPSIIIB, MIM:252920) also known as Sanfilippo syndrome type B (Beesley et al. 2005). Authored: Jassal, B, 2011-10-19 EC Number: 3.2.1.50 Edited: Jassal, B, 2011-10-19 Pubmed16151907 Pubmed8776591 Reactome Database ID Release 431678742 Reactome, http://www.reactome.org ReactomeREACT_121018 Reviewed: D'Eustachio, P, 2012-03-28