Alpha-N-acetylglucosaminidase (NAGLU) hydrolyses another N-acetyl-D-glucosamine residue from heparan Alpha-N-acetylglucosaminidase (NAGLU) also hydrolyses another non-reducing, terminal N-acetyl-D-glucosamine residue from heparan sulfate. The active form of the enzyme (77kDa) is derived from an 82kDa precursor (Weber et al. 1996). Defects in NAGLU cause Mucopolysaccharidosis type IIIB (MPSIIIB, MIM:252920), also known as Sanfilippo syndrome type B (Beesley et al. 2005). Authored: Jassal, B, 2012-02-06 EC Number: 3.2.1.50 Edited: Jassal, B, 2012-02-06 Pubmed16151907 Pubmed8776591 Reactome Database ID Release 432090038 Reactome, http://www.reactome.org ReactomeREACT_120723 Reviewed: D'Eustachio, P, 2012-03-28