HS(4)-PGs HS(3)-PGs HS3ST1 sulfates GlcN at C3 in heparan sulfate Authored: Jassal, B, 2012-01-27 EC Number: 2.8.2.23 Edited: Jassal, B, 2012-01-27 Heparan sulfate 3-O-sulfotransferase1 (HS3ST1) transfers sulfate to the 3-OH position on glucosamine (GlcN) residues of heparan sulfate (HS) to form 3-O-sulfated HS. HS3ST1 is the rate limiting enzyme for synthesis of anticoagulant heparan sulfate. Unlike the other members of the HS3ST family, it is probably located in the Golgi lumen (Shworak et al. 1997). Pubmed9346953 Reactome Database ID Release 432076383 Reactome, http://www.reactome.org ReactomeREACT_120741 Reviewed: D'Eustachio, P, 2012-03-28