HS(5)-PGs HS/HPIN-PGs HS6STs sulfate GlcN at C6 in heparan sulfate/heparin Authored: Jassal, B, 2012-01-27 Edited: Jassal, B, 2012-01-27 Heparan-sulfate 6-O-sulfotransferases 1 and 2 (HS3ST1-2) (Habuchi et al. 1998, Habuchi et al. 2003 respectively) catalyze the transfer of sulfate to C6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. A third member HS3ST3 that may also mediate this reaction has been characterised in mouse (Habuchi et al. 2000) but remains uncharacterised in humans. It can be argued that this structure can now be called either heparan sulfate- or heparin-PG. Pubmed10644753 Pubmed12492399 Pubmed9535912 Reactome Database ID Release 432076419 Reactome, http://www.reactome.org ReactomeREACT_120849 Reviewed: D'Eustachio, P, 2012-03-28