HS core proteins HS/HPIN-PGs Heparanase 2 (HPSE2) cleaves heparan sulfate from its proteoglycan (plasma membrane) Authored: Jassal, B, 2011-10-19 Edited: Jassal, B, 2011-10-19 Heparanase 2 (HPSE2) (McKenzie et al. 2000) is a membrane-bound endoglycosidase that cleaves heparan sulfate (HS) from its HS proteoglycan (HSPG), either in the extracellular matrix or the basement membranes of cells. Defects in HPSE2 are the cause of urofacial syndrome (UFS) (MIM:236730) (Daly et al. 2010, Pang et al. 2010). Pubmed11027606 Pubmed20560209 Pubmed20560210 Reactome Database ID Release 431678694 Reactome, http://www.reactome.org ReactomeREACT_120961 Reviewed: D'Eustachio, P, 2012-03-28