Gal-Gal-Xyl-proteins GlcA-Gal-Gal-Xyl-proteins A glucuronate moiety is the fourth addition to the tetrasaccharide linker Authored: Jassal, B, 2011-11-01 B3GAT1 (Kitagawa et al. 1998), 2 (Marcos et al. 2002) and 3 (Ouzzine et al. 2000) transfer a glucuronate residue via a beta1,3-linkage to a terminal galactose. The B3GATs are homodimeric and require manganese as a cofactor (Kakuda et al. 2004, Ouzzine et al. 2000). The tetrasaccharide linker is now complete, ready to accept further hexosamine additions. The type of hexosamine added is critical in determining which glycosaminoglycan (GAG) is formed. EC Number: 2.4.1.135 Edited: Jassal, B, 2011-11-01 Pubmed10842173 Pubmed12522689 Pubmed14993226 Pubmed9506957 Reactome Database ID Release 431889955 Reactome, http://www.reactome.org ReactomeREACT_120897 Reviewed: D'Eustachio, P, 2012-03-28