Heparan(4)-PGs Heparan(3)-PGs NDST1-4 N-deacetylates GlcNAc residues in heparan Authored: Jassal, B, 2011-12-01 EC Number: 3.5.1.33 Edited: Jassal, B, 2011-12-01 Pubmed11087757 Pubmed16343444 Pubmed7601448 Pubmed9915799 Reactome Database ID Release 432022887 Reactome, http://www.reactome.org ReactomeREACT_121110 Reviewed: D'Eustachio, P, 2012-03-28 The bifunctional enzymes heparan sulfate N-deacetylase/N-sulfotransferase 1-4 (NDST1-4) catalyse both the N-deacetylation and the N-sulfation of N-acetylglucosamine (GlcNAc) of heparan (Dixon et al. 1995, Duncan et al. 2006, Aikawa & Esko 1999, Aikawa et al. 2001). The N-deacetylation of a GlcNAc residue to a glucosamine residue is shown here.