ISGylated IRF3 PIN1 mediated IRF3 degradation 'ISGylated IRF3 [cytosol]' negatively regulates 'PIN1 mediated IRF3 degradation' INHIBITION Pubmed16914094 Pubmed20153823 Reactome Database ID Release 431176076 Reactome, http://www.reactome.org ReactomeREACT_27981 The transcription factor IRF3 is a target for ISGylation. Conjugation of ISG15 positively regulates IRF3 and thereby promotes induction of type I interferons. ISGylation of IRF3 prevents the binding of PIN1, a protein that promotes IRF3 ubiquitination and subsequent degradation.