HYAL2 interacts with NHE1 to create an acidic environment Authored: Jassal, B, 2012-03-05 Edited: Jassal, B, 2012-03-05 Hyaluronidases are only active in acidic environments. HYAL2 can interact with the Na+-H+ exchanger NHE1 which can create an acidic microenvironment in the caveolae. Extracellular Na+ ions are exchanged for protons which creates the acidic conditions required for the activity of HYAL2. Pubmed15090545 Reactome Database ID Release 432160884 Reactome, http://www.reactome.org ReactomeREACT_120879 Reviewed: D'Eustachio, P, 2012-03-28 HA:HAR:HYAL2 HA:HAR:HYAL2:SLC9A1