HA polymer HA receptors Receptor-mediated uptake of HA Authored: Jassal, B, 2012-03-05 Edited: Jassal, B, 2012-03-05 HA receptors mediate the uptake of HA into cells. CD44 consists of four functional domains, the extracellular distal domain being the HA-binding region (Culty et al. 1990, Asher & Bignami 1992). The receptor for hyaluronan mediated motility (RHAMM, also called HMMR) can bind HA but not heparin or chondroitin sulfate (Assmann et al. 1998, Wang et al. 1996). Lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE1) removes HA from the lymphatic system (Banerji et al. 1999). It is present mainly on lymphatic endothelial cells but also in liver sinusoids. Hyaluronan receptor for endocytosis (HARE, stabilin-2, STAB2) binds to and mediates endocytosis of HA (Harris et al. 2007, Harris et al. 2004). HARE can also bind other glycosaminoglycans such as heparin (Harris et al. 2008).<br>High molecular weight HA is tethered to the cell surface by HA receptors and the GPI-linked hyaluronidase 2 (HYAL2) to form a HA:HAR:HYAL2 complex in the plasma membrane that localizes to caveolae (invaginations of the plasma membrane composed of cholesterol and gangliosides and rich in caveolin and flotillin). Pubmed10037799 Pubmed1426053 Pubmed15208308 Pubmed1703543 Pubmed17145755 Pubmed18434317 Pubmed8890751 Pubmed9601098 Reactome Database ID Release 432160915 Reactome, http://www.reactome.org ReactomeREACT_120787 Reviewed: D'Eustachio, P, 2012-03-28 HA:HAR:HYAL2