6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ Cytosolic phosphogluconate dehydrogenase (PGD) catalyzes the reaction of 6-phospho-D-gluconate and NADP+ to form D-ribulose 5-phosphate, CO2, and NADPH + H+ (Beutler and Kuhl 1985; Rippa et al. 1998). The PGD enzyme is dimeric (Dallocchio et al. 1985). EC Number: 1.1.1.44 Pubmed3932573 Pubmed3994686 Pubmed9920387 Reactome Database ID Release 4371299 Reactome, http://www.reactome.org ReactomeREACT_611