SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate Authored: D'Eustachio, P, 2008-11-29 15:37:01 Edited: D'Eustachio, P, 2008-11-29 15:37:01 Pubmed11417227 Pubmed15151999 Reactome Database ID Release 43378513 Reactome, http://www.reactome.org ReactomeREACT_15324 Reviewed: Jassal, B, 2008-11-26 09:32:08 SLC7A11 as a heterodimer with SLC3A2 in the plasma membrane mediates the exchange of glutamate and cysteine. Under physiological conditions, cytosolic glutamate concentrations are high and cysteine concentrations are low, so glutamate is exported and cysteine imported. SLC7A11 is widely expressed in the body (Bassi et al. 2001; Gasol et al. 2004).