SLC43A1 (LAT3)-mediated uptake of large neutral amino acids Authored: D'Eustachio, P, 2008-06-02 20:10:30 Edited: D'Eustachio, P, 2008-06-02 20:10:30 Pubmed12930836 Reactome Database ID Release 43352103 Reactome, http://www.reactome.org ReactomeREACT_13479 Reviewed: Jassal, B, 2008-06-03 13:06:01 SLC43A1 (LAT3), associated with the plasma membrane, mediates the uptake of isoleucine, leucine, methionine, phenylalanine, and valine in a biphasic and sodium ion-independent transport process. Northern blotting experiments indicate gene expression in liver, pancreas, and skeletal muscle, and at lower levels in many tissues including kidney and intestine (Babu et al. 2003). ligands of SLC43A1 and SLC43A2 ligands of SLC43A1 and SLC43A2