SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine Authored: D'Eustachio, P, 2008-06-02 20:10:30 Edited: D'Eustachio, P, 2008-06-02 20:10:30 Pubmed10823827 Pubmed11243884 Reactome Database ID Release 43352174 Reactome, http://www.reactome.org ReactomeREACT_13659 Reviewed: Jassal, B, 2008-06-03 13:06:01 SLC38A3 (SN1), associated with the plasma membrane, mediates the uptake of glutamine, histidine, and, with lower efficiency, alanine and asparagine. Uptake of one molecule of amino acid is coupled to the uptake of two sodium ions and the export of one H+. Northern blotting experiments indicate gene expression in liver and kidney, and at much lower levels in brain, lung, skeletal muscle, spleen, stomach, testis, kidney, and intestine (Fei et al. 2000; Nakanishi et al. 2001). has a Stoichiometric coefficient of 2 ligands of SLC38A3 ligands of SLC38A3