GCK1:GKRP complex glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex Edited: D'Eustachio, P, 2006-02-20 18:39:56 Glucokinase (GCK1) reversibly binds glucokinase regulatory protein (GKRP) to form an inactive complex. Binding is stimulated by fructose 6-phosphate and sorbitol 6-phosphate (hence high concentrations of these molecules tend to reduce GCK1 activity) and inhibited by fructose 1-phosphate (hence a high concentration of this molecule tends to increase GCK1 activity) (Brocklehurst et al. 2004). Pubmed14627435 Reactome Database ID Release 43170824 Reactome, http://www.reactome.org ReactomeREACT_6771