alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate EC Number: 3.1.3.9 Glucose-6-phosphatase associated with the inner face of the endoplasmic reticulum membrane catalyzes the hydrolysis of glucose-6-phosphate to glucose and orthophosphate (reviewed by Van Scaftingen and Gerin 2002). This reaction is essentially irreversible. Defects in glucose-6-phosphatase are the cause of glycogen storage disease type 1a (Lei et al. 1995; Guionie et al, 2003; Petrolonis et al, 2004). Pubmed11879177 Pubmed12965222 Pubmed14722102 Pubmed7573034 Reactome Database ID Release 4371825 Reactome, http://www.reactome.org ReactomeREACT_1682 Reviewed: Harris, RA, 2008-09-10 18:47:12