Transport (influx) of fructose by GLUT5 Authored: D'Eustachio, P, 2006-11-03 14:36:07 Edited: D'Eustachio, P, 2006-11-04 20:44:47 Pubmed1550217 Pubmed1634504 Reactome Database ID Release 43189222 Reactome, http://www.reactome.org ReactomeREACT_9449 Reviewed: Wright, EM, 2007-01-15 21:00:45 The reversible transport of extracellular fructose into the cytosol is mediated by GLUT5. In the small intestine, GLUT5 is localized on the lumenal surfaces of enterocytes (Davidson et al. 1992) and thus mediates the uptake of dietary fructose, which can be released into the circulation in a separate transport step mediated by basolaterally localized GLUT2. The specificity of GLUT5 has been worked out by studying sugar transport in Xenopus oocytes expressing recombinant human GLUT5 protein (Burant et al. 1992). extracellular fructose => cytosolic fructose