Transport (influx) of glucose, galactose, and sodium ions by SGLT1 Authored: D'Eustachio, P, 2006-11-03 14:36:07 Edited: D'Eustachio, P, 2006-11-04 20:44:47 Pubmed12885248 Pubmed15546855 Pubmed8563765 Reactome Database ID Release 43189208 Reactome, http://www.reactome.org ReactomeREACT_9525 Reviewed: Wright, EM, 2007-01-15 21:00:45 The transport of extracellular glucose and galactose into the cytosol, coupled to the uptake of two sodium ions for each hexose transported is mediated by SGLT1. In the small intestine, SGLT1 is localized on the lumenal surfaces of enterocytes and thus mediates the uptake of dietary glucose and galactose, which can be released into the circulation in a separate transport step mediated by basolaterally localized GLUT2 (Wright et al. 2004). The specificity of SGLT1 has been worked out by studying sugar transport in plasma membrane vesicles containing recombinant human SGLT1 protein (Quick et al. 2003). Consistent with these in vitro results, children lacking functional SGLT1 protein fail to absord dietary glucose and galactose (Martin et al. 1996). has a Stoichiometric coefficient of 2 galactose, glucose galactose, glucose