Transport (efflux) of fructose, galactose, and glucose by GLUT2 Authored: D'Eustachio, P, 2006-11-03 14:36:07 Edited: D'Eustachio, P, 2006-11-04 20:44:47 Pubmed1701966 Pubmed8457197 Pubmed9354798 Pubmed9751501 Reactome Database ID Release 43189242 Reactome, http://www.reactome.org ReactomeREACT_9458 Reviewed: Wright, EM, 2007-01-15 21:00:45 The reversible facilitated diffusion of fructose, galactose, and glucose from the cytosol to the extracellular space is mediated by the GLUT2 transporter in the plasma membrane. In the epithelial cells of the small intestine, the basolateral localization of GLUT2 (Thorens et al. 1990) enables hexose sugars derived from the diet and taken up by the action of the SGLT1 and GLUT5 transporters to be released into the circulation. The specificity of the GLUT2 transporter has been established directly through biochemical assays of purified recombinant proteins (Colville et al. 1993; Wu et al. 1998) and indirectly through studies of patients deficient in GLUT2 transporter protein (Santer et al. 1997). cytosolic fructose, galactose, or glucose => extracellular fructose, galactose, or glucose fructose, galactose, glucose fructose, galactose, glucose