SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine Authored: D'Eustachio, P, 2008-11-29 15:37:01 Edited: D'Eustachio, P, 2008-11-29 15:37:01 Pubmed10903140 Reactome Database ID Release 43379426 Reactome, http://www.reactome.org ReactomeREACT_15318 Reviewed: Jassal, B, 2008-11-26 09:32:08 SLC7A6 as a heterodimer with SLC3A2 in the plasma membrane mediates the exchange of arginine for leucine and a sodium ion. The physiological concentrations of arginine and leucine are expected to favor arginine export. By the criterion of Northern blotting, SLC7A6 is expressed in a variety of tissues (Broer et al. 2000).