TGFB1:TGFBR2:p-TGFBR1:Smad7:NEDD4L TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-Smad7 ubiquitin NEDD4L ubiquitinates Smad7 and TGFBR1 Authored: Orlic-Milacic, M, 2012-04-04 Edited: Jassal, B, 2012-04-10 NEDD4L, recruited to the activated TGF-beta receptor complex by Smad7, ubiquitinates TGFBR1. Ubiquitination of Smad7 by NEDD4L has not been examined in this context (Kuratomi et al. 2005). Pubmed15496141 Reactome Database ID Release 432176427 Reactome, http://www.reactome.org ReactomeREACT_121321 Reviewed: Huang, Tao, 2012-05-14 has a Stoichiometric coefficient of 2