SLC7A9-mediated exchange of extracellular arginine, lysine, or cystine for cytosolic leucine Authored: D'Eustachio, P, 2008-11-29 15:37:01 Edited: D'Eustachio, P, 2008-11-29 15:37:01 Pubmed11318953 Reactome Database ID Release 43379432 Reactome, http://www.reactome.org ReactomeREACT_15542 Reviewed: Jassal, B, 2008-11-26 09:32:08 SLC7A9 as a heterodimer with SLC3A1 in the plasma membrane mediates the exchange of arginine, lysine, or cystine for leucine. The physiological concentrations of these amino acids favor leucine export and arginine / lysine / cystine import. Defects in SLC7A9 and SLC3A1 are associated with cystinuria. In the body, this transport process is prominent in the kidney (Mizoguchi et al. 2001). arginine, cystine, lysine arginine, cystine, lysine