oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] EC Number: 4.1.1.32 Oxaloacetate and GTP react to form phosphoenolpyruvate, CO2, and GDP [cytosol] Pubmed11851336 Reactome Database ID Release 4370241 Reactome, http://www.reactome.org ReactomeREACT_259 Reviewed: Harris, RA, 2008-09-10 18:47:12 The transfer of a high-energy phosphate bond from GTP to oxaloacetate, to form phosphoenolpyruvate, GDP, and CO2, is catalyzed by cytosolic phosphoenolpyruvate carboxykinase (Dunten et al. 2002). This reaction is irreversible under physiological conditions.