Exchange of cytosolic glutamate and mitochondrial aspartate Authored: D'Eustachio, P, 2008-09-12 21:47:19 Edited: D'Eustachio, P, 2008-09-12 21:47:19 Pubmed10369257 Pubmed10642534 Pubmed11566871 Reactome Database ID Release 43372448 Reactome, http://www.reactome.org ReactomeREACT_14830 Reviewed: Harris, RA, 2008-09-10 18:47:12 SLC25A12 and SLC25A13, located in the inner mitochondrial membrane, each mediate the exchange of cytosolic aspartate and mitochondrial glutamate. The exchange is physiologically irreversible because of the potential across the inner mitochondrial membrane (positive outside, negative inside). In the body, SLC25A12 (ARALAR1) is found mainly in heart, skeletal muscle, and brain, while SCL25A13 (CITRIN) is widely expressed but most abundant in liver (del Arco et al. 2000; Palmieri et al. 2001). Defects in SLC25A13 are associated with type II citrullinemia (Kobayashi et al. 1999). aspartate [mitochondrial matrix] + glutamate [cytosol] => aspartate [cytosol] + glutamate [mitochondrial matrix]