Exchange of malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane Authored: D'Eustachio, P, 2007-06-22 14:17:01 Edited: D'Eustachio, P, 2008-09-12 22:05:52 Pubmed16920706 Pubmed4687397 Pubmed8597574 Reactome Database ID Release 43198440 Reactome, http://www.reactome.org ReactomeREACT_11181 Reviewed: Harris, RA, 2008-09-10 18:47:12 The SLC25A11 transport protein in the inner mitochondrial membrane mediates the reversible exchange of mitochondrial malate and cytosolic alpha-ketoglutarate (2-oxoglutarate). Qualitative evidence for this process comes from studies of the human protein (Kabe et al. 2006); kinetic details are inferred from stdies of rat mitochondria under conditions in which only the one transport protein appears to be active (Sluse et al. 1973). The dimeric state of the transport protein is inferred from studies of its bovine homologue (Bisaccia et al. 1996). malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]