SMAD7:RNF111 Ub-SMAD7 ubiquitin RNF111 ubiquitinates SMAD7 Authored: Orlic-Milacic, M, 2012-04-04 EC Number: 6.3.2.19 Edited: Jassal, B, 2012-04-10 Pubmed14657019 RNF111 (Arkadia) polyubiquitinates SMAD7 (Koinuma et al. 2003). This was inferred from studies using recombinant mouse Smad7 and recombinant mouse Rnf111 expressed in human embryonic kidney cell line HEK293. Reactome Database ID Release 432186785 Reactome, http://www.reactome.org ReactomeREACT_120848 Reviewed: Huang, Tao, 2012-05-14