MYC gene MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex Authored: Orlic-Milacic, M, 2012-04-04 Complex formed by RBL1 (p107), E2F4/5, DP1/2 and a trimer of phosphorylated R-SMADs (SMAD2/3) and SMAD4 (Co-SMAD) cooperatively binds to TIE (TGF-beta inhibitory element) and E2F sites in the MYC promoter and promotes cell-cycle independent inhibition of MYC transcription in response to TGF-beta stimulation (Chen et al. 2002). Edited: Jassal, B, 2012-04-10 Pubmed12150994 Reactome Database ID Release 431484099 Reactome, http://www.reactome.org ReactomeREACT_121295 Reviewed: Huang, Tao, 2012-05-14