p-2S-SMAD2/3:SMAD4:MEN1 p-2S-SMAD2/3:SMAD4 MEN1 binds SMAD2/3:SMAD4 heterotrimer Authored: Orlic-Milacic, M, 2012-04-04 Edited: Jassal, B, 2012-04-10 MEN1 (menin), a transcription factor tumor suppressor mutated in a familial cancer syndrome multiple endocrine neoplasia type 1, binds SMAD2/3:SMAD4 heterotrimer through interaction with SMAD3. MEN1 likely acts as a trancriptional cofactor for SMAD2/3:SMAD4 and may be involved in transcriptional regulation of some SMAD2/3:SMAD4 target genes (Kaji et al. 2001, Sowa et al. 2004, Canaff et al. 2012). Pubmed11274402 Pubmed15150273 Pubmed22275377 Reactome Database ID Release 432186643 Reactome, http://www.reactome.org ReactomeREACT_120994 Reviewed: Huang, Tao, 2012-05-14