CSL NICD coactivator complex PCAF NICD CSL MAML CBP SNW Formation of CSL-NICD coactivator complex Authored: Caudy, M, 2008-09-05 23:43:34 Mammalian CSL Coactivator Complexes: Upon activation of Notch signaling, cleavage of the transmembrane Notch receptor releases the Notch Intracellular Domain (NICD), which translocates to the nucleus, where it binds to CSL and displaces the corepressor complex from CSL (reviewed in Mumm, 2000 and Kovall, 2007). The resulting CSL-NICD "binary complex" then recruits an additional coactivator, Mastermind (Mam), to form a ternary complex. The ternary complex then recruits additional, more general coactivators, such as CREB Binding Protein (CBP), or the related p300 coactivator, and a number of Histone Acetytransferase (HAT) proteins, including GCN5 and PCAF (Fryer, 2002). There is evidence that Mam also can subsequently recruit specific kinases that phosphorylate NICD, to downregulate its function and turn off Notch signaling (Fryer, 2004). Reactome Database ID Release 43212356 Reactome, http://www.reactome.org ReactomeREACT_14814 Reviewed: Baker, N, 2008-06-05 07:19:32