Formation of Malonyl-CoA from Acetyl-CoA (muscle) Authored: Gopinathrao, G, 2007-07-29 21:03:03 Cytosolic acetyl-CoA carboxylase 1 (ACACA) catalyzes the reaction of bicarbonate, ATP, and acetyl-CoA to form malonyl-CoA, ADP, and orthophosphate. The reaction is positively regulated by citrate. The human ACACA cDNA has been cloned (Abu-Elheiga et al. 1995) and the biochemical properties of the human enzyme have recently been described (Cheng et al. 2007; Locke et al. 2008). Four ACACA isoforms generated by alternative splicing have been identified as mRNAs - the protein product of the first has been characterized experimentally. EC Number: 6.4.1.2 Pubmed10677481 Pubmed17223360 Pubmed9099716 Reactome Database ID Release 4375851 Reactome, http://www.reactome.org ReactomeREACT_590 Reviewed: D'Eustachio, P, 2007-07-31 18:50:15