dsRNA duplex Formation of dsRNA structure by looping Authored: Gopinathrao, G, 2003-12-05 16:34:53 Reactome Database ID Release 4377612 Reactome, http://www.reactome.org ReactomeREACT_1276 Site-specific A to I conversion requires dsRNA structures present around the editing site. These structures can be formed by exonic sequences and neighboring intronic sequences. An editing-site complementary sequence (ECS) has been identified in mice. Although minimal requirements for A to I editing have been identified, detailed mechanisms describing the individual steps are not yet well studied in humans.<BR> nascent pre-mRNA transcript