Integrin MAC-1 Integrin alphaMbeta2:JAM3 MAC1 binds JAM-C Authored: Ouwehand, W.H., 2007-11-12 16:45:54 Pubmed17379836 Pubmed17525755 Reactome Database ID Release 43202727 Reactome, http://www.reactome.org ReactomeREACT_12035 Recruitment of monocytic cells to the vessel wall by platelets is mediated via CD11b/CD18 (Mac-1) and platelet JAM-C. In the case of dendritic cells, this interaction leads to their activation and platelet phagocytosis. This process may be of importance for progression of atherosclerotic lesions. Reviewed: Zwaginga, JJ, 2007-11-12 16:47:00