Plasmin plasminogen:histidine-rich glycoprotein plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) Authored: D'Eustachio, P, 2005-02-14 18:06:15 EC Number: 3.4.21 Edited: D'Eustachio, P, 0000-00-00 00:00:00 Plasminogen, tethered to the cell surface by its association with histidine-rich glycoprotein, is rapidly cleaved and activated to plasmin by the action of urokinase plasminogen activator(two-chain form) bound to uPAR, its cell-surface receptor. The association of both substrate and enzyme with the cell surface is necessary for the reaction to proceed efficiently (Ellis et al. 1989, 1991). Pubmed1829461 Pubmed2521625 Reactome Database ID Release 43158925 Reactome, http://www.reactome.org ReactomeREACT_598