Grb2 bound to Tie2 pTie2:Ang-1 Interaction of Tie2 and Grb2 Authored: Garapati, P V, de Bono, B, 2008-03-05 10:26:56 Pubmed10521483 Pubmed11191051 Pubmed14749497 Pubmed7478529 Reactome Database ID Release 43204871 Reactome, http://www.reactome.org ReactomeREACT_12511 Reviewed: Trowsdale, J, 2008-02-26 12:02:59 Tie2/Tek provide mitogenic signals to endothelial cells by promoting the association of Grb2 to one of their phosphotyrosines. Grb2 is an adaptor protein that has been linked to activation of Ras and mitogen activated protein kinase (MAPK) cell growth signaling pathways. Grb2 also binds to the Y1102 of the kinase domain of Tie2 with one of its SH2 doamins.