p85 bound to Tie2 PI3K pTie2:Ang-1 Interaction of Tie2 and p85 of PI3K Authored: Garapati, P V, de Bono, B, 2008-03-05 10:26:56 Edited: Garapati, P V, 2009-03-16 17:55:42 Pubmed10521483 Pubmed9632797 Reactome Database ID Release 43204798 Reactome, http://www.reactome.org ReactomeREACT_12475 Reviewed: Trowsdale, J, 2008-02-26 12:02:59 The p85 subunit of phosphatidylinositol 3-kinase (PI3-kinase) associates with Tie2, most likely at phosphotyrosine 1102. This association leads on to the activation of Akt/PKB, a process linked to cell survival and antiapoptosis, and that may in part account for Tie2's role in vascular growth and maintenance.