Tie2 and Ang4 complex Interaction of Tie2 and Ang4 Ang4 represents a third protein of the Ang family that binds to the Tie2 receptor. The mouse Ang3 and human Ang4 are interspecies orthologs. Ang4 acts as an activating ligand and induces phosphorylation in Tie2. Authored: Garapati, P V, de Bono, B, 2008-03-05 10:26:56 Pubmed10051567 Pubmed11969368 Pubmed15284220 Reactome Database ID Release 43204824 Reactome, http://www.reactome.org ReactomeREACT_12598 Reviewed: Trowsdale, J, 2008-02-26 12:02:59