Tie2 and Dok-2 complex pTie2:Ang-1 Interaction of Tie2 and Dok-2 Authored: Garapati, P V, de Bono, B, 2008-03-05 10:26:56 Dok-2 is a member of a docking proteins class, termed the DOK family. The DOK family members are characterized by an N-terminal pleckstrin homology (PH) domain followed by a central PTB domain and a proline- and tyrosine-rich C-terminal tail. Dok-2 is recruited to activated Tie2 via its PTB domain, which results in its subsequent tyrosine phosphorylation, thereby establishing binding sites for the small GTPase-activating protein for Ras, p120RasGAP (RasGAP) and the adapter protein Nck. The binding of DOK to the receptor leads to Nck recruitment and subsequent phosphorylation. Binding of Pak to Nck follows. this brings about the Ang-1-dependent phosphorylation of Pak in endothelial cells. Pubmed11689432 Pubmed12665569 Pubmed9764820 Reactome Database ID Release 43204850 Reactome, http://www.reactome.org ReactomeREACT_12575 Reviewed: Trowsdale, J, 2008-02-26 12:02:59