pTie2:SHC1 complex pTie2:Ang-1 Interaction of Tie2 and Shc1 Authored: Garapati, P V, de Bono, B, 2008-03-05 10:26:56 Edited: Garapati, P V, 2009-03-16 17:55:42 Pubmed14665640 Reactome Database ID Release 43204861 Reactome, http://www.reactome.org ReactomeREACT_12409 Reviewed: Trowsdale, J, 2008-02-26 12:02:59 ShcA, an SH2-containing adapter protein, acts as a scaffold for the assembly of signaling proteins involved in the activation of the Ras-MAPK pathway, and potentially other signaling pathways. <br>ShcA is one of the binding partners of endogenous Tie2 receptor on vascular endothelial cells. After Tie2 stimulation by Ang-1 interaction, ShcA associates with Tie2 and becomes tyrosine-phosphorylated. ShcA interacts with the cytoplasmic domain of Tie2 and Y1102 of Tie2 was identified as the primary binding site for the SH2 domain of ShcA. ShcA leads to a reduction of tyrosine phosphorylation of p85 subunit of PI3-kinase and is involved in the inhibition of endothelial cell migration and survival.