CD48 bound to CD244 CD48 binds CD244 Authored: Ouwehand, W.H., 2007-11-12 16:45:54 CD2, CD48, CD84, CD244 and CD58 have a similar extracellular domain arichitecture consisting of two IgSF domains. CD244 is closely related to CD84 in having a long cytoplasmic tail with tyrosine-based motifs (TxYxxI/V) resembling immunoreceptor tyrosine-based inhibitory motifs (ITIMs). CD2 has a cytoplasmic domain with proline-rich regions which recruit an Src homology 3 (SH3)- containing protein called CD2-associated protein (CD2AP). CD48 is glycosyl-phosphatidyl-inositol (GPI)-anchored to the membrane.<p> CD244 is known to be activated by binding to CD48 in humans. Pubmed10764623 Pubmed16585556 Reactome Database ID Release 43202722 Reactome, http://www.reactome.org ReactomeREACT_12018 Reviewed: Zwaginga, JJ, 2007-11-12 16:47:00