TREM-1 bound to its ligand Ligand to TREM-1 on the platelet membrane Platelet-derived TREM-1 ligand binds to TREM-1 Authored: Ouwehand, W.H., 2007-11-12 16:45:54 Pubmed17452516 Pubmed18192027 Reactome Database ID Release 43203156 Reactome, http://www.reactome.org ReactomeREACT_12047 Reviewed: Zwaginga, JJ, 2007-11-12 16:47:00 The triggering receptor expressed on myeloid cells 1 (TREM-1) plays an important role in the innate immune response related to severe infections and sepsis. Although the identity and occurrence of the natural TREM-1 ligands are so far unknown, the presence of a ligand for TREM-1 on human platelets has been established. It has been suggested that TREM1 recognizes soluble proteins or cell-surface proteins which are upregulated as a result of inflammation and/or tissue damage and also bacterial LPS (Tessarz & Cerwenka 2008).