Complex of Tie2:Ang-1 Tie2/Ang1 dimer Dimerization of Tie2/Ang1 complex Authored: Garapati, P V, de Bono, B, 2008-03-05 10:26:56 Pubmed11080633 Pubmed14749497 Reactome Database ID Release 43210881 Reactome, http://www.reactome.org ReactomeREACT_12431 Receptor tyrosine kinase activation and signaling are typically initiated via dimerization of the receptors through homo-oligomeric ligand binding. <br><br>Angiopoietin1 may form homotrimers, but in most cases it assembles into higher-order multimers. This oligomerization is mediated by the N-ter coiled coil domain (CCD). <br>The binding of Ang1 oligomers to Tie2 promotes the dimerization of Tie2, which is further assisted by the interaction between the kinase domains of the receptors. Reviewed: Trowsdale, J, 2008-02-26 12:02:59 has a Stoichiometric coefficient of 2