Tie2/Ang1 dimer Phosphorylated Tie2 in Tie2/Akt dimer Trans-phosphorylation of Tie2 Authored: Garapati, P V, de Bono, B, 2008-03-05 10:26:56 EC Number: 2.7.10 Pubmed12665569 Pubmed14749497 Pubmed9632797 Reactome Database ID Release 43210872 Reactome, http://www.reactome.org ReactomeREACT_12496 Reviewed: Trowsdale, J, 2008-02-26 12:02:59 The dimerization of Tie2 leads to autophosphorylation and activation of its kinase domain. There are multiple tyrosine phosphorylation sites in the Tie2 kinase domain. The phosphorylated tyrosine residues provide the interaction site for the SH2 domains of other downstream signaling molecules like PI3K, Grb2, SHP2 etc. has a Stoichiometric coefficient of 12